High-sensitivity monitoring of ctDNA by patient-specific sequencing panels and integration of variant reads
J. C. Wan, K. Heider, D. Gale, S. Murphy, E. Fisher, J. Morris, F. Mouliere, D. Chandrananda, A. Marshall, A. B. Gill, P. Y. Chan, E. Barker, G. Young, W. N. Cooper, I. Hudecova, , N. Rosenfeld
This paper introduces INVAR, a method to improve ctDNA detection sensitivity using patient-specific sequencing panels and variant read integration, achieving ppm-level detection in clinical samples.
bioRxiv · Sep 11, 2019 · PreprintCancer Biology