S. Murphy

Acod1 Expression in Cancer Cells Promotes Immune Evasion through the Generation of Inhibitory Peptides

This study shows that Acod1 in cancer cells promotes immune evasion by releasing inhibitory peptides, not ITA, and that reducing Acod1 can make tumors responsive to PD-1 therapy.

Overcome Prostate Cancer Resistance to Immune Checkpoint Therapy with Ketogenic Diet-Induced Epigenetic Reprogramming

This study shows that combining ketogenic diet and HDAC inhibitors with ICB therapy enhances anti-tumor effects in prostate cancer by modulating epigenetic and immune mechanisms.

In vitro evidence against productive SARS-CoV-2 infection of human testicular cells: Bystander effects of infection mediate testicular injury.

This study shows SARS-CoV-2 does not directly infect human testicular cells but causes injury through bystander effects from systemic inflammation or viral antigens.

R-loop homeostasis and cancer mutagenesis promoted by the DNA cytosine deaminase APOBEC3B

This study shows APOBEC3B regulates R-loop homeostasis and contributes to mutagenesis in cancer by binding R-loops and altering their landscape.

Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2

This study shows that delayed type I and III interferon responses in nasal epithelial cells allow SARS-CoV-2 replication, but pre-infection IFN treatment restricts virus and preserves barrier integrity.

Red Blood Cells Function as DNA Sensors

The paper shows red blood cells detect and bind DNA, triggering immune responses during infections.

PDE9 Inhibition Activates PPARa to Stimulate Mitochondrial Fat Metabolism and Reduce Cardiometabolic Syndrome

This study shows PDE9 inhibition activates PPARa to enhance mitochondrial fat metabolism and reduce cardiometabolic syndrome in mice, with potential for treating obesity in men and postmenopausal women.

Sampling strategies for modelling above ground biomass using optimal imagery and LiDAR metrics

The paper discusses sampling strategies for modelling above ground biomass using optimal imagery and LiDAR metrics but has been withdrawn due to issues with referencing.

Structural basis of peptidoglycan endopeptidase regulation

This study solves the crystal structure of ShyA, a peptidoglycan endopeptidase, revealing a regulatory mechanism involving conformational changes that activate its catalytic activity.

High-sensitivity monitoring of ctDNA by patient-specific sequencing panels and integration of variant reads

This paper introduces INVAR, a method to improve ctDNA detection sensitivity using patient-specific sequencing panels and variant read integration, achieving ppm-level detection in clinical samples.

Large particle fluorescence-activated cell sorting enables high quality single cell RNA-sequencing and functional analysis of adult cardiomyocytes

This study demonstrates that large-particle fluorescence-activated cell sorting (LP-FACS) improves the isolation of viable adult cardiomyocytes, enabling high-quality single-cell RNA sequencing and functional analysis.

Asymmetric Division Promotes Therapeutic Resistance In Glioblastoma Stem Cells

The paper shows that asymmetric division in glioblastoma stem cells generates daughter cells with enhanced therapeutic resistance and co-inherited growth factor receptors.

Spatial Capture-Recapture for Categorically Marked Populations with An Application to Genetic Capture-Recapture

The paper introduces a categorical spatial partial identity model (SPIM) to improve density estimation in populations with uncertain individual identity, showing it performs better than existing methods in high uncertainty scenarios.