G. Young

Myosin-5 varies its steps along the irregular F-actin track

This study reveals that myosin-5 takes variable step lengths along F-actin tracks, adapting to angular disorder in the track structure.

Tiny Earth CURE improves student persistence in science

This study shows that the Tiny Earth CURE improves scientific self-efficacy, identity, and persistence intentions among students, particularly those from historically excluded communities.

A dual role for CRTH2 in acute lung injury

This study investigates CRTH2's role in acute lung injury, finding it promotes neutrophil survival but suppresses neutrophilic inflammation via IL-4.

Dissemination and pathogenesis of toxigenic Clostridium perfringens strains linked to neonatal intensive care units and Necrotising Enterocolitis

This study identifies hypervirulent C. perfringens strains linked to NEC in preterm infants, showing their dissemination between hospitals and increased virulence.

Label-free tracking and massmeasurement of single proteins onlipid bilayers

This paper introduces dynamic mass photometry to track and measure single membrane proteins, revealing that dynamin1 forms dimers rather than tetramers during oligomerization.

Endocast and bony labyrinth of a stem gnathostome shed light on the earliest diversification of jawed vertebrates

The study analyzes the endocast and bony labyrinth of a 400-million-year-old fossil fish, suggesting that early jawed vertebrate relationships may need to be re-evaluated.

Dual blockade of IL-6 and CTLA-4 regresses pancreatic tumors in a CD4+ T cell-dependent manner.

This study shows dual IL-6 and CTLA-4 blockade regresses pancreatic tumors via CD4+ T cells and CXCR3-dependent mechanisms.

Quantifying the heterogeneity of macromolecular machines by mass photometry

This paper demonstrates that mass photometry accurately quantifies sample heterogeneity with high resolution and minimal volume, outperforming negative stain electron microscopy in detecting proteasome assemblies.

High-sensitivity monitoring of ctDNA by patient-specific sequencing panels and integration of variant reads

This paper introduces INVAR, a method to improve ctDNA detection sensitivity using patient-specific sequencing panels and variant read integration, achieving ppm-level detection in clinical samples.

A report on the detection and management of a finding of PSTVd (Potato Spindle Tuber Viroid) in potato breeding material in Northern Ireland, UK.

This paper reports the detection of PSTVd in potato breeding material in Northern Ireland and describes eradication efforts and risk assessment.

Primary infection with dengue or Zika virus does not affect the severity of heterologous secondary infection in macaques.

This study investigates whether prior dengue or Zika virus infection affects the severity of subsequent heterologous secondary infections in macaques, finding no significant impact on clinical outcomes.

Quantitative mass imaging of single molecules in solution

This paper introduces a method to mass-image single biomolecules in solution with high precision and resolution, enabling the study of molecular interactions and assemblies.