Myostatin is a major endocrine driver of follicle-stimulating hormone synthesis
L. Ongaro, X. Zhou, Y. Wang, Z. Zhou, H. Schultz, E. R. S. Buddle, E. Brule, Y.-F. Lin, G. Schang, R. Castonguay, Y. Liu, G. H. Su, N. Seidah, K. C. Ray, S. J. Karp, , D. J. Bernard
The paper identifies myostatin as an endocrine hormone that promotes pituitary FSH synthesis and ovarian function, challenging the previous role of activins and highlighting potential fertility risks of myostatin antagonists.
bioRxiv · Aug 30, 2023 · PreprintPhysiology