Surface crosslinking of virus-like particles increases resistance to proteases, low pH and mechanical stress for mucosal applications
A. Ali, S. Ganguillet, Y. Turgay, T. Keys, E. Causa, R. Fradique, V. Lutz-Bueno, S. Chesnov, C.-W. Lin, V. Lentsch, J. Kotar, P. Cicuta, R. Mezzenga, E. Slack, M. Radiom
This study enhances the stability of virus-like particles (VLPs) against environmental stressors by surface crosslinking, without affecting their vaccine function.
bioRxiv · Jul 29, 2023 · PreprintBiophysics