L. Vallier

Immunogenicity of autologous and allogeneic human primary cholangiocyte organoids

The immune response to human primary cholangiocyte organoids is ameliorated by donor-recipient HLA matching.

Novel 3D Approach to Model Non-Alcoholic Fatty Liver Disease using human Pluripotent Stem Cells

This paper develops a 3D multicellular model of NAFLD using hiPSC-derived liver cells to study disease mechanisms and interactions.

Assessing motile cilia coverage and beat frequency in mammalian in-vitro cell culture tissues

This paper introduces an automated method to assess cilia coverage and beat frequency in mammalian in vitro cell cultures using video microscopy.

Limited oxygen availability in standard cell culture alters metabolism and function in terminally-differentiated cells

This study shows that increasing oxygen levels in cell culture improves metabolic function and responsiveness in terminally differentiated cells like adipocytes and hepatocytes.

Regenerative and non-regenerative transcriptional states of the human epicardium: from foetus to adult and backagain

This study compares foetal and adult human epicardium using single-cell RNA sequencing to identify regenerative programs and their absence in adults, suggesting ways to enhance cardiac regeneration.

TGFβ signalling is required to maintain pluripotency of human naïve pluripotent stem cells

This study shows that TGFβ signalling maintains naive human pluripotency by regulating SMAD2/3 binding and gene expression, with distinct effects compared to primed hPSCs.

FXR inhibition reduces ACE2 expression, SARS-CoV-2 infection and may improve COVID-19 outcome

This study shows FXR inhibition lowers ACE2 expression, reduces SARS-CoV-2 infection, and correlates with better clinical outcomes in COVID-19.

Epigenetic regulations follow cell cycle progression during differentiation of human pluripotent stem cells.

This study investigates epigenetic changes during the first two cell divisions of human pluripotent stem cell differentiation using synchronized cultures and identifies key regulatory mechanisms.

Transcriptional networks are dynamically regulated during cell cycle progression in human Pluripotent Stem Cells

The paper shows that transcriptional networks and chromatin dynamics change during the cell cycle in human embryonic stem cells.

GMP-grade neural progenitor derivation and differentiation from clinical-grade human embryonic stem cells

This paper presents a GMP-compliant protocol to derive and differentiate clinical-grade human embryonic stem cells into neuroepithelial stem cells with neurogenic potential.

Single-cell sequencing of developing human gut reveals transcriptional links to childhood Crohns disease

The paper maps the developing human gut at 6-10 weeks post-conception using single-cell sequencing and links fetal transcriptional patterns to childhood Crohn's disease.

GDF15 and the beneficial actions of metformin in pre-diabetes

This study shows metformin increases GDF15 levels, which is necessary for its weight loss and insulin-sensitizing effects in both humans and mice.