C.-W. Lin

A gut meta-interactome map reveals modulation of human immunity by microbiome effectors

The paper identifies a gut microbiome meta-interactome map showing how bacterial effectors modulate human immunity and are enriched in Crohn's disease.

Surface crosslinking of virus-like particles increases resistance to proteases, low pH and mechanical stress for mucosal applications

This study enhances the stability of virus-like particles (VLPs) against environmental stressors by surface crosslinking, without affecting their vaccine function.

A two-component protein condensate of EGFR and Grb2 regulates Ras activation at the membrane

This study shows that EGFR and Grb2 form a condensate that regulates Ras activation through phosphorylation and dimerization.

Functional analysis of Ost3p and Ost6p containing yeast oligosaccharyltransferases

This study functionally analyzes Ost3p and Ost6p subunits in yeast OST, showing their roles in catalytic activity and substrate specificity.

Glycan-Protein Interactions Determine Kinetics of N-Glycan Remodeling

The paper investigates how glycan-protein interactions influence the kinetics of N-glycan remodeling using molecular dynamics simulations and biochemical assays.

Dihydroceramide desaturase promotes the formation of intraluminal vesicles and inhibits autophagy to increase exosome production

This study shows that DEGS1/Ifc promotes exosome production by enhancing intraluminal vesicle formation and inhibiting autophagic degradation of multivesicular endosomes in Drosophila.

Recapitulating the frataxin activation mechanism in an engineered bacterial cysteine desulfurase supports the architectural switch model

The paper engineers a bacterial cysteine desulfurase to recapitulate the frataxin activation mechanism, supporting the architectural switch model by showing FXN compensates for lost subunit interactions.