Author

E. D. Egan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

S. C. Blacklow· 3 shared A. P. Martin· 1 shared C. H. Lipper· 1 shared D. Antfolk· 1 shared D. Gonzalez-Perez· 1 shared E. Medina· 1 shared G. Scanavachi· 1 shared J. C. Aster· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCell Biology

S. C. Blacklow

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Temporal Dynamics and Stoichiometry in Notch Signaling - from Notch Synaptic Complex Formation to NICD Nuclear Entry

L. Tveriakhina, G. Scanavachi, E. D. Egan, R. B. D. C. Correia, A. P. Martin, J. M. Rogers, J. S. Yodh, J. C. Aster, T. Kirchhausen, S. C. Blacklow

This study tracks Notch and Delta interactions in real-time, showing 1:1 stoichiometry at synapses and NICD nuclear entry after 45 minutes, inhibited by signaling blockers.

bioRxiv · Sep 27, 2023 · PreprintCell Biology

Structural Basis for Selective Proteolysis of ADAM10 Substrates at Membrane-Proximal Sites

C. H. Lipper, E. D. Egan, K.-H. Gabriel, S. C. Blacklow

This study determines the cryo-EM structure of ADAM10-Tspan15 complex, revealing how Tspan15 relieves autoinhibition and positions the active site for membrane-proximal substrate cleavage.

bioRxiv · Oct 22, 2022 · PreprintBiochemistry

An affinity-matured DLL4 ligand for broad-spectrum activation and inhibition of Notch signaling

D. Gonzalez-Perez, S. Das, E. Medina, D. Antfolk, E. D. Egan, S. C. Blacklow, P. C. Rodriguez, V. C. Luca

This study develops DeltaMAX, an affinity-matured DLL4 ligand that broadly activates or inhibits Notch signaling in human and murine systems.

bioRxiv · Mar 7, 2022 · PreprintBioengineering