ImmunologybioRxivPreprint
Defining the mechanisms of action and resistance to the anti-PD-1+LAG-3 and anti-PD-1+CTLA-4 combinations in melanoma flank and brain models
M. Phadke, J. Li, Z. Chen…·K. S. Smalley
This study investigates the mechanisms of action and resistance of anti-PD-1+LAG-3 and anti-PD-1+CTLA-4 combinations in melanoma models, finding differential effects on CD4+ T cell polarization and CD8+ T cell function.
DOI 10.1101/2023.04.14.536907