Cell BiologyCell ReportsPeer-reviewed
Clustering-based positive feedback between a kinase and its substrate enables effective T-cell receptor signaling
E. Dine, E. H. Reed, J. E. Toettcher
The paper uses an optogenetic system to show that clustering of Zap70 and LAT enhances downstream signaling compared to dimers, revealing a positive feedback loop involving Src-family kinases.
DOI 10.1016/j.celrep.2021.109280