Identification and Characterization of the First Fragment Hits for SETDB1 Tudor Domain
P. Mader, R. Mendoza-Sanchez, A. Iqbal, A. Dong, E. Dobrovetsky, V. Corless, S. Liew, S. Houliston, R. Ferreira De Freitas, D. Smil, C. Dela Sena, S. Kennedy, D. Diaz, H. Wu, L. Dombrovski, , C. Arrowsmith
The paper identifies small molecule fragments that bind to the tudor domain of SETDB1 and describes their binding modes and biophysical properties.
Bioorganic & Medicinal Chemistry · Sep 1, 2019Peer-reviewedPharmacology & Toxicology