Pathophysiological regulation of lung function by the free fatty acid receptor FFA4
A. B. Tobin, R. Prihandoko, D. Kaur, C. H. Wiegman, E. Alvarez-Curto, C. Donovan, L. Chachi, T. Ulven, M. R. Tyas, E. Euston, Z. Dong, A. G. Alharbi, R. Kim, J. G. Lowe, P. M. Hansbro, , G. Milligan
This study shows that activating FFA4 reduces airway resistance in mouse models of inflammation and human lung tissue, suggesting it could be a therapeutic target for asthma and COPD.
bioRxiv · May 18, 2020Pharmacology & Toxicology