Cancer BiologybioRxiv
HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma
D. J. Garcia-Dominguez, N. Hajji, S. Sanchez-Molina…·L. Hontecillas-Prieto
This study shows HDAC6 regulates EWSR1-FLI1 expression in Ewing sarcoma by modulating SP1 acetylation and promoter binding, with HDAC6 inhibition reducing oncogenic activity and enhancing treatment response.
DOI 10.1038/s41388-021-01974-4