Author

E. Fitzpatrick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 5 Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:human· 4 Research Focus:differential expression· 3 Research Focus:cell signaling & trafficking· 2 Approach:deep learning· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

C. Lally· 5 shared P. A. Cahill· 4 shared M. Di Luca· 3 shared P. S. Mathieu· 3 shared B. Tornifoglio· 2 shared D. Burtenshaw· 2 shared E. M. Redmond· 2 shared R. Hakimjavadi· 2 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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5 shared papersBioengineering

C. Lally

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Machine Learning-Guided Antibody Engineering That Leverages Domain Knowledge To Overcome The Small Data Problem

T. Clark, V. Subramanian, A. Jayaraman, E. Fitzpatrick, R. Gopal, N. Pentakota, T. Rurak, S. Anand, A. Viglione, K. Tharakaraman, R. Raman, R. Sasisekharan

This paper presents a machine learning platform that enhances antibody affinity and neutralizing potency using domain knowledge and limited experimental data.

bioRxiv · Jun 2, 2023 · PreprintBioengineering

Exploring DTI-derived metrics to non-invasively track recellularisation in vascular tissue engineering

B. Tornifoglio, A. J. Stone, P. S. Mathieu, E. Fitzpatrick, C. Kerskens, C. Lally

This study uses DTI to non-invasively track recellularisation in vascular grafts, showing changes in fractional anisotropy correlate with cell density.

bioRxiv · Jul 15, 2022 · PreprintBioengineering

A short-term decellularisation technique for porcine carotid arteries that conveys a structural stimulus to cells

E. Fitzpatrick, R. Gaul, C. Smekens, P. S. Mathieu, B. Meehan, B. Tornifoglio, P. A. Cahill, C. Lally

This paper describes a short-term decellularization technique for porcine carotid arteries that preserves structure and mechanical properties, producing an acellular graft suitable for vascular bypass.

bioRxiv · Jun 28, 2022 · PreprintBioengineering

Native Extracellular Matrix Orientation Determines Multipotent Vascular Stem Cell Proliferation in Response to Cyclic Uniaxial Tensile Strain and Simulated Stent Indentation

P. S. Mathieu, E. Fitzpatrick, M. Di Luca, P. A. Cahill, C. Lally

This study shows that multipotent vascular stem cells (MVSC) proliferate more when aligned with collagen fibers under cyclic tensile strain, suggesting a role in in-stent restenosis.

bioRxiv · Dec 11, 2020Bioengineering

Collagen fibre-mediated mechanical damage increases calcification of bovine pericardium for use in bioprosthetic heart valves

A. Whelan, E. Williams, E. Fitzpatrick, B. Murphy, P. S. Gunning, D. O'Reilly, C. Lally

This study shows mechanical damage increases calcification in bovine pericardium used for bioprosthetic heart valves, with calcification varying spatially based on damage levels.

bioRxiv · Oct 21, 2020Bioengineering

The calcium binding protein S100β marks hedgehog-responsive resident vascular stem cells within vascular lesions

M. Di Luca, E. Fitzpatrick, D. Burtenshaw, W. Liu, J.-C. Helt, R. Hakimjavadi, E. Corcoran, Y. Gusti, D. Sheridan, S. Harman, C. Lally, E. M. Redmond, P. A. Cahill

This study identifies S100β-expressing vascular stem cells that respond to hedgehog signaling and contribute to vascular lesion formation in atherosclerosis.

bioRxiv · May 20, 2020 · PreprintCell Biology

Disease-relevant single cell photonic signatures identify S100β stem cells and their myogenic progeny in vascular lesions

C. Molony, D. King, M. di Luca, M. Kitching, A. Olayinka, R. Hakimjavadi, L. A. Julius, E. Fitzpatrick, Y. Gusti, D. Burtenshaw, K. Healy, E. K. Finlay, D. Kernan, A. Llobera, W. Liu, , P. A. Cahill

bioRxiv · May 13, 2020Cell Biology

Inhibition and down regulation of the serotonin transporter contribute to the progression of degenerative mitral regurgitation

R. J. Levy, E. Fitzpatrick, E. Castillero, , H. J. Shukla, , V. V. Inamdar, A. E. Aghali, J. B. Grau, N. Rioux, E. Salvati, S. J. Keeney, I. Nissim, R. C. C. Gorman, L. Rauova, S. J. Stachelek, C. R. Brown, , G. Ferrari

This study investigates how inhibition and downregulation of the serotonin transporter (SLC6A4) contribute to the progression of degenerative mitral regurgitation through enhanced HTR2B signaling.

bioRxiv · Mar 10, 2020 · PreprintPhysiology