E. Williams

HIGH THROUGHPUT QUANTITATION OF HUMAN NEUTROPHIL RECRUITMENT AND FUNCTIONAL RESPONSES IN AN AIR-BLOOD BARRIER ARRAY

The paper develops a high-throughput assay to study neutrophil recruitment and function in an air-blood barrier array, showing improved throughput and sample efficiency compared to existing methods.

Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors

The paper identifies fragment binders and mutationally intolerant sites in Zika virus NS2B-NS3 protease to develop resistance-resilient antiviral inhibitors.

Human Saliva Modifies Growth, Biofilm Architecture and Competitive Behaviors of Oral Streptococci

This study shows that human saliva affects growth, biofilm structure, and competitive interactions between oral streptococci species.

Human Digital Twin: Automated Cell Type Distance Computation and 3D Atlas Construction in Multiplexed Skin Biopsies

The paper develops a 3D workflow to analyze multiplexed skin biopsy data, revealing age-related changes in DNA repair and immune cell ratios.

Time-Dependent Increase in Susceptibility and Severity of Secondary Bacterial Infection during SARS-CoV-2 Infection

This study shows that SARS-CoV-2 infection increases susceptibility and severity of secondary bacterial infection in mice, with time-dependent effects on immune responses and lethality.

A basement membrane discovery pipeline uncovers network complexity, new regulators, and human disease associations

The paper develops a pipeline to identify BM-associated proteins, finds new regulators, and links BM genes to human disease.

Mechanistic understanding enables the rational design of salicylanilide combination therapies for Gram-negative infections

This paper identifies mechanisms of niclosamide action and resistance in Gram-negative bacteria and demonstrates synergistic combination therapies with efflux inhibitors and membrane permeabilizers.

Collagen fibre-mediated mechanical damage increases calcification of bovine pericardium for use in bioprosthetic heart valves

This study shows mechanical damage increases calcification in bovine pericardium used for bioprosthetic heart valves, with calcification varying spatially based on damage levels.

Peripheral sgp130-mediated trans-signaling blockade induces obesity and insulin resistance in mice via PPARα suppression

This study shows that blocking peripheral sgp130-mediated trans-signaling in mice causes obesity and insulin resistance by suppressing PPARα.

Identification, Mapping and Relative Quantitation of SARS-CoV-2 Spike Glycopeptides by Mass-Retention Time Fingerprinting

The paper introduces a method to identify, map, and quantify SARS-CoV-2 Spike glycopeptides using mass-retention time fingerprinting with LC-TOF mass spectrometry.

A Ribosome Interaction Surface Sensitive to mRNA GCN Periodicity

The paper identifies a ribosome surface that interacts with mRNA GCN codons, showing sequence-specific hydrogen bonding that influences translation regulation.

Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30

This study shows that inhibiting both mitochondrial translation and dynamics in C. elegans synergistically extends lifespan through HLH-30-dependent lysosome biogenesis and autophagy.