Single-cell RNA sequencing identifies SLC6A3 as a biomarker and prognostic marker in clear cell renal cell carcinoma
S. P. Narayanan, R. Gopal, A. J. Sebastian, T. Masoodi
bioRxiv · Aug 31, 2023 · PreprintCancer Biology
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R. Gopal
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2018-2023 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 9 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
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Recent·Most cited
Machine Learning-Guided Antibody Engineering That Leverages Domain Knowledge To Overcome The Small Data Problem
T. Clark, V. Subramanian, A. Jayaraman, E. Fitzpatrick, R. Gopal, N. Pentakota, T. Rurak, S. Anand, A. Viglione, K. Tharakaraman, R. Raman, R. Sasisekharan
This paper presents a machine learning platform that enhances antibody affinity and neutralizing potency using domain knowledge and limited experimental data.
bioRxiv · Jun 2, 2023 · PreprintBioengineering
SARS-CoV-2-specific memory B cells can persist in the elderly despite loss of neutralising antibodies
A. Jeffery-Smith, A. R. Burton, S. Lens, C. Rees-Spear, M. Patel, R. Gopal, L. Muir, F. Aiano, K. J. Doores, J. Y. Chow, S. N. Ladhani, M. Zambon, L. E. McCoy, M. K. Maini
Circulating class-switched spike and RBD-specific memory B cells can outlast detectable neutralising antibodies but are functionally constrained in the elderly.
bioRxiv · May 30, 2021 · PreprintImmunology
Y-RNAs Lead an Endogenous Program of RIG-I Agonism Mobilized upon RNA Virus Infection and Targeted by HIV
N. Vabret, V. Najburg, A. Solovyov, P. Sulc, S. Balan, G. Beauclair, M. Chazal, H. Varet, R. Legendre, O. Sismeiro, R. Sanchez David, C. McClain, R. Gopal, L. Chauveau, O. Schwartz, , A. Komarova
This study identifies Y-RNAs as endogenous RIG-I ligands that are targeted by HIV through DUSP11 downregulation, enhancing their immunogenicity and triggering antiviral responses.
bioRxiv · Sep 18, 2019Immunology