Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection
D. VanDyke, M. Iglesias, J. Tomala, A. Young, J. Smith, J. A. Perry, E. Gebara, A. R. Cross, L. S. Cheung, A. G. Dykema, B. T. Orcutt-Jahns, T. Henclova, J. Golias, J. Balolong, L. M. Tomasovic, , J. B. Spangler
The paper engineers a cytokine/antibody fusion protein that selectively expands regulatory T cells and protects against autoimmune diseases in mouse models.
bioRxiv · May 29, 2022Bioengineering