Author

D. VanDyke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:CITE-seq· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. B. Spangler· 3 shared A. G. Dykema· 2 shared D. M. Pardoll· 2 shared L. M. Tomasovic· 2 shared L. S. Cheung· 2 shared A. J. Munoz· 1 shared A. Michaud· 1 shared A. R. Cross· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersImmunology

J. B. Spangler

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Author profile →

3 papers

Recent·Most cited

Synergistic activity of IL-2 mutein with tolerogenic ImmTOR nanoparticles leads to massive expansion of antigen-specific Tregs and protection against autoimmune disease

T. K. Kishimoto, M. Fournier, A. Michaud, G. Rizzo, C. Roy, T. Capela, N. Nukolova, N. Li, L. Doyle, F.-n. Fu, D. VanDyke, P. G. Traber, J. B. Spangler, S. S. Leung, P. O. Ilyinskii

This study shows that combining IL-2 mutein with ImmTOR nanoparticles expands antigen-specific Tregs and protects against autoimmune diseases.

bioRxiv · May 15, 2023 · PreprintImmunology

Lung tumor-infiltrating Treg have divergent transcriptional profiles and function linked to checkpoint blockade response

A. G. Dykema, J. Zhang, B. Zhang, L. S. Cheung, Z. Zeng, C. M. Cherry, T. Li, J. X. Caushi, M. Nishimoto, S. Connor, Z. Ji, A. J. Munoz, W. Hou, W. Zhan, D. Singh, , K. N. Smith

The paper identifies 10 subsets of lung cancer-infiltrating Tregs, showing one subset is suppressive and linked to anti-PD-1 resistance while another is Th1-like and associated with PD-1 response.

bioRxiv · Dec 13, 2022 · PreprintImmunology

Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection

D. VanDyke, M. Iglesias, J. Tomala, A. Young, J. Smith, J. A. Perry, E. Gebara, A. R. Cross, L. S. Cheung, A. G. Dykema, B. T. Orcutt-Jahns, T. Henclova, J. Golias, J. Balolong, L. M. Tomasovic, , J. B. Spangler

The paper engineers a cytokine/antibody fusion protein that selectively expands regulatory T cells and protects against autoimmune diseases in mouse models.

bioRxiv · May 29, 2022Bioengineering