GATA2 haploinsufficiency causes an epigenetic feedback mechanism resulting in myeloid and erythroid dysplasia
E. Gioacchino, W. Zhang, C. Koyunlar, J. Zink, H. de Looper, K. J. Gussinklo, R. Hoogenboezem, D. Bosch, E. Bindels, I. P. Touw, E. de Pater
This study shows that GATA2 haploinsufficiency in zebrafish leads to epigenetic feedback increasing Gata2b expression, causing myeloid and erythroid dysplasia through lineage differentiation defects.
bioRxiv · Oct 29, 2021 · PreprintCancer Biology