Age-associated Senescent - T Cell Signaling Promotes Type 3 Immunity that Inhibits Regenerative Response
J. Han, C. Cherry, J. C. Mejias, A. Ruta, D. R. Maestas, A. Pena, H. H. Nguyen, B. Yang, E. Gray-Gaillard, N. Rutkowski, K. Krishnan, A. J. Tam, E. J. Fertig, F. Housseau, S. Ganguly, , J. H. Elisseeff
This study shows that age-related senescent T cells promote type 3 immunity, which inhibits tissue repair, and that blocking this pathway improves healing in older animals.
bioRxiv · Aug 17, 2021 · PreprintBioengineering