A. Pena

MYBPHL nonsense mutations have poor sarcomere binding, are degraded, and cause abnormal contraction

The paper investigates MYBPHL nonsense mutations, showing they impair sarcomere incorporation, lead to protein degradation, and cause contractile defects in cardiomyocytes.

Proteolytic degradation of atrial sarcomere proteins underlies contractile defects in atrial fibrillation

This study identifies proteolytic degradation of atrial sarcomere proteins as a mechanism underlying contractile defects in atrial fibrillation.

A non-genetic model of vascular shunts informs on the cellular mechanisms of formation and resolution of arteriovenous malformations

This study identifies EC volume changes as the key mechanism for AV shunt formation and regression, using a non-genetic model in mice.

Age-associated Senescent - T Cell Signaling Promotes Type 3 Immunity that Inhibits Regenerative Response

This study shows that age-related senescent T cells promote type 3 immunity, which inhibits tissue repair, and that blocking this pathway improves healing in older animals.

Endothelial cell invasiveness is controlled by myosin IIA-dependent inhibition of Arp2/3 activity

The paper identifies myosin IIA's role in inhibiting Arp2/3 activity to regulate endothelial tip cell protrusions during sprouting angiogenesis.

The mechanism of selective kinesin inhibition by kinesin binding protein.

This study identifies how kinesin binding protein selectively inhibits specific kinesins by structurally distorting their motor domains and blocking microtubule attachment.

OmpK36 and TraN facilitate conjugal transfer of the Klebsiella pneumoniae carbapenem resistance plasmid pKpQIL

This study identifies OmpK36 and TraN as key factors for conjugative transfer of the K. pneumoniae plasmid pKpQIL, revealing a novel receptor mechanism for IncF plasmids.

Near-atomic cryo-EM structure of yeast kinesin 5-microtubule complex reveals a distinct binding footprint

The paper determines the near-atomic structure of yeast kinesin-5 bound to microtubules, revealing conserved and distinct features of the motor-microtubule interface.