Author

A. Ruta

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. Cherry· 2 shared D. M. Pardoll· 2 shared E. J. Fertig· 2 shared F. Housseau· 2 shared H. H. Nguyen· 2 shared J. C. Mejias· 2 shared J. H. Elisseeff· 2 shared K. Krishnan· 2 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersBioengineering

C. Cherry

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Transfer learning of an in vivo-derived senescence signature identifies conserved and tissue-specific senescence across species and diverse pathologies

C. Cherry, J. I. Andorko, K. Krishnan, J. C. Mejias, H. H. Nguyen, K. B. Stivers, E. F. Gray-Gaillard, A. Ruta, N. Hamada, M. Hamada, I. Sturmlechner, S. Trewartha, J. H. Michel, L. D. Huyer, M. T. Wolf, , J. H. Elisseeff

The paper develops a transfer learning approach to identify senescent cells across species and tissues using an in vivo-derived gene expression signature, revealing conserved and tissue-specific senescence features.

bioRxiv · Mar 22, 2022 · PreprintBioengineering

Age-associated Senescent - T Cell Signaling Promotes Type 3 Immunity that Inhibits Regenerative Response

J. Han, C. Cherry, J. C. Mejias, A. Ruta, D. R. Maestas, A. Pena, H. H. Nguyen, B. Yang, E. Gray-Gaillard, N. Rutkowski, K. Krishnan, A. J. Tam, E. J. Fertig, F. Housseau, S. Ganguly, , J. H. Elisseeff

This study shows that age-related senescent T cells promote type 3 immunity, which inhibits tissue repair, and that blocking this pathway improves healing in older animals.

bioRxiv · Aug 17, 2021 · PreprintBioengineering