ImmunologybioRxiv
SLC15A4 controls endolysosomal TLR7-9 responses by recruiting the innate immune adaptor TASL.
H. Zhang, L. Bernaleau, M. Delacretaz…·M. Rebsamen
This study shows SLC15A4 recruits TASL to endolysosomes to control TLR7-9 signaling, independent of its transport function, and identifies this interaction as a therapeutic target for SLE.
DOI 10.1016/j.celrep.2023.112916