ATP-release pannexin channels are gated by lysophospholipids
E. Henze, R. N. Burkhardt, B. W. Fox, T. J. Schwertfeger, E. Gelsleichter, K. Michalski, L. Kramer, M. Lenfest, J. M. Boesch, H. Lin, F. C. Schroeder, T. Kawate
The paper identifies lysophospholipids as activators of pannexin channels, showing they trigger ATP and other metabolite release, and activate inflammasomes in human monocytes.
bioRxiv · Oct 23, 2023Biophysics