Author

L. Kramer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 2 Bioengineering· 1 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Assay:proteomics· 4 Organism:Arabidopsis· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:ecology & biodiversity· 2

Frequent Co-Authors

A. Ciota· 3 shared A. Payne· 3 shared A. Vigneron· 2 shared L. Kuo· 2 shared M. Onyango· 2 shared A. F. Coskun· 1 shared A. J. Friedman· 1 shared A. Ochal· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

A. Ciota

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Multi-Niche Human Bone Marrow On-A-Chip for Studying the Interactions of Adoptive CAR-T Cell Therapies with Multiple Myeloma

D. Ghoshal, I. Petersen, R. Ringquist, L. Kramer, E. Bhatia, T. Hu, A. Richard, R. Park, J. Corbin, S. Agarwal, A. Thomas, S. Ramirez, J. Tharayil, E. Downey, F. Ketchum, , K. Roy

This study develops a 3D bone marrow-on-a-chip model to investigate interactions between CAR-T cells and multiple myeloma cells in different niches and assess therapeutic responses.

bioRxiv · Apr 8, 2024 · PreprintCancer Biology

Multi-Omics Analysis Of Antiviral Interactions Of Elizabethkingia anophelis And Zika Virus

S. F. Omme, J. Wang, M. Sifuna, J. Rodriguez, R. Owusu, M. Goli, P. Jiang, W. Purba, J. Nwaiwu, C. Brelsfoard, A. Vigneron, L. Kramer, A. Ciota, Y. Mechref, M. G. Onyango

This study investigates the antiviral interactions between Elizabethkingia anophelis and Zika virus using multi-omics analysis, revealing attenuated viral replication and altered metabolic pathways.

bioRxiv · Dec 27, 2023 · PreprintMicrobiology

ATP-release pannexin channels are gated by lysophospholipids

E. Henze, R. N. Burkhardt, B. W. Fox, T. J. Schwertfeger, E. Gelsleichter, K. Michalski, L. Kramer, M. Lenfest, J. M. Boesch, H. Lin, F. C. Schroeder, T. Kawate

The paper identifies lysophospholipids as activators of pannexin channels, showing they trigger ATP and other metabolite release, and activate inflammasomes in human monocytes.

bioRxiv · Oct 23, 2023Biophysics

A biophysical rationale for the selective inhibition of PTP1B over TCPTP by nonpolar terpenoids

A. J. Friedman, H. M. Padgette, L. Kramer, E. T. Liechty, G. W. Donovan, J. M. Fox, M. R. Shirts

The paper investigates how nonpolar terpenoids selectively inhibit PTP1B over TCPTP by disrupting conserved allosteric networks, with differences in amino acid conservation at specific sites enabling this selectivity.

bioRxiv · Apr 17, 2023 · PreprintBioengineering

Revealing how variations in antibody repertoires correlate with vaccine responses

Y. Safonova, S. B. Shin, L. Kramer, J. Reecy, C. T. Watson, T. P. L. Smith, P. A. Pevzner

The paper analyzes antibody repertoire variations in vaccinated calves to identify genetic factors influencing vaccine efficacy against bovine respiratory disease.

bioRxiv · Aug 6, 2021Immunology

Challenges of γ9δ2TCR affinity maturation when using phage display

L. Kramer, M. Demuysere, E. van Diest, D. Beringer, J. Kuball

This study attempts to enhance the functional avidity of γ9δ2TCR through affinity maturation using phage display but fails due to instability of the scTCR format in bacterial expression.

bioRxiv · May 20, 2021 · PreprintImmunology

Potential for transmission of Elizabethkingia anophelis by Aedes albopictus and the role of microbial interactions in Zika virus competence

M. Onyango, A. Payne, J. Stout, C. Dieme, L. Kuo, A. Ciota, L. Kramer

The paper demonstrates that Elizabethkingia anophelis is present in Aedes mosquito saliva and inhibits Zika virus replication in midguts, suggesting vector-borne transmission potential and a novel transmission barrier for arboviruses.

bioRxiv · Mar 27, 2020 · PreprintMicrobiology

Increased temperatures reduce the vectorial capacity of Aedes mosquitoes for Zika virus

m. Onyango, S. Bialosuknia, A. Payne, N. Mathias, L. Kuo, A. Vigneron, M. DeGennaro, A. Ciota, l. kramer

This study shows that increased temperatures reduce the vectorial capacity of Aedes mosquitoes for Zika virus, with greater effects on Ae. aegypti than Ae. albopictus.

bioRxiv · Jul 14, 2019Microbiology

Extensive recoding of dengue virus type 2 specifically reduces replication in primate cells without gain-of-function in Aedes aegypti mosquitoes

C. B. Stauft, S. H. Shen, Y. Song, O. Gorbatsevych, E. Asare, B. Futcher, S. Mueller, A. Payne, M. Brecher, L. Kramer, E. Wimmer

bioRxiv · Jul 9, 2018Microbiology