Modeling of Intracellular Taurine Levels Associated with Ovarian Cancer Reveals Activation of p53, ERK, mTOR and DNA-damage-sensing-dependent Cell Protection
D. Centeno, S. Farsinejad, E. Kochetkova, T. Volpari, A. Gladych-Macioszek, A. Klupczynska - Gabryszak, T. Polotaye, M. Greenberg, D. Kung, E. Hyde, S. Alshehri, T. Pavlovic, W. Sullivan, S. Plewa, H. Vakifahmetoglu-Norberg, , M. Iwanicki
This study shows that increasing intracellular taurine in ovarian cancer cells reduces proliferation, glycolysis, and DNA damage, while activating protective pathways like p53 and mTOR.
bioRxiv · Feb 24, 2023Cancer Biology