Placental uptake and metabolism of 25(OH)Vitamin D determines its activity within the fetoplacental unit
B. Ashley, C. Simner, A. Manousopoulou, C. Jenkinson, F. Hey, J. M. Frost, F. I. Rezwan, C. H. White, E. M. Lofthouse, E. Hyde, L. Cooke, S. Barton, P. Mahon, E. M. Curtis, R. J. Moon, , J. K. Cleal
This study shows the human placenta actively transports and metabolizes 25(OH)D3 into active vitamin D metabolites, influencing fetal development through placental transcriptome and proteome changes.
eLife · Mar 8, 2022Peer-reviewedPhysiology