E. J. Olson

Systematic analysis of low-affinity transcription factor binding site clusters in vitro and in vivo establishes their functional relevance

The paper systematically analyzes low-affinity transcription factor binding site clusters in vitro and in vivo, showing they can achieve substantial occupancies and drive transcriptional activation.

Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes

This paper introduces hydrazine-based chemoproteomic probes to target cofactor-dependent enzymes, enabling enzyme discovery and drug development through diverse functional profiling.