Darapladib, an inhibitor of Lp-PLA2, sensitizes cancer cells to ferroptosis by remodeling lipid metabolism
M. Oh, S. Y. Jang, J.-Y. Lee, J. W. Kim, Y. Jung, J. Seo, T.-S. Han, E. Jang, H. Y. Son, D. Kim, M. W. Kim, K.-H. Song, K.-J. Oh, W. K. Kim, K.-H. Bae, , E.-W. Lee
This study shows that darapladib, an Lp-PLA2 inhibitor, enhances ferroptosis in cancer cells by altering lipid metabolism and synergizes with GPX4 inhibitors to suppress tumor growth.
bioRxiv · Apr 8, 2023 · PreprintCancer Biology