Y. Jung

Spatial Transcriptomics Reveals Spatially Diverse Cancer-Associated Fibroblast in Lung Squamous Cell Carcinoma Linked to Tumor Progression

This study uses spatial transcriptomics to analyze cancer-associated fibroblasts in lung squamous cell carcinoma, linking their spatial organization to tumor progression and patient outcomes.

Modeling platinum resistance in a stem-like patient-derived ovarian cancer sample

This study develops a patient-derived model of cisplatin resistance in ovarian cancer stem-like cells and identifies molecular and functional changes associated with resistance.

Implantable nanophotonic neural probes for integrated patterned photostimulation and electrophysiology recording

This paper introduces implantable nanophotonic neural probes that enable patterned photostimulation and electrophysiology recording with minimal thermal damage.

Enhanced functionalities of immune cells separated by microfludic lattice: assessment based on holotomography

This study compares microfluidic and centrifugation methods for isolating white blood cells, finding microfluidic separation better preserves cell functionality.

Darapladib, an inhibitor of Lp-PLA2, sensitizes cancer cells to ferroptosis by remodeling lipid metabolism

This study shows that darapladib, an Lp-PLA2 inhibitor, enhances ferroptosis in cancer cells by altering lipid metabolism and synergizes with GPX4 inhibitors to suppress tumor growth.

Synthetic lipid rafts formed by cholesterol nano-patch induce early T cell activation

This study uses cholesterol nano-patches to show that spatial cholesterol arrangement induces early T cell activation by forming synthetic lipid rafts and reorganizing signaling molecules.

Single-cell analysis of non-alcoholic fatty livers identifies a role for the constitutive androstane receptor

The paper uses single-cell RNA sequencing to identify lipid synthesis clusters and links the constitutive androstane receptor to hepatic steatosis in NAFLD.

Effect of dietary zinc supplementation on the gastrointestinal microbiota and host gene expression in the Shank3B-/- mouse model of autism spectrum disorder

This study examines how dietary zinc affects the gut microbiota and host gene expression in Shank3B-/- mice, showing changes in microbial communities and host metabolism linked to autism-like behaviors.

Cytotoxic Effect of Silver Ions in Combination with Peanut's leaf extract on Cells

This study investigates the effect of silver ions combined with peanut leaf extract on anti-inflammatory activity, showing enhanced effects in nitric oxide assays.

The combined toxicity test of polyester and tetra ethylene glycol on Daphnia magna

This study tests the toxicity of polyester and tetra ethylene glycol on Daphnia magna, finding that polyester is more toxic than tetra ethylene glycol, and their combination has synergistic adverse effects.

Implantable photonic neural probes for light-sheet fluorescence brain imaging

The paper introduces implantable photonic neural probes that enable light-sheet fluorescence imaging in brain tissues without additional micro-optic components.

TLR7 ligation augments haematopoiesis in Rps14 (uS11) deficiency via paradoxical suppression of inflammatory signalling and enhanced differentiation

This study identifies imiquimod, a TLR7 agonist, as a therapeutic for MDS by enhancing haematopoiesis through paradoxical anti-inflammatory effects and increased differentiation.

CD45 pre-exclusion from the tips of microvilli establishes a phosphatase-free zone for early TCR triggering

The paper shows CD45 is pre-excluded from microvilli tips on T cells, enabling early TCR triggering before stable immunological synapse formation.

Single-cell transcriptomics reveals zone-specific alterations of liver sinusoidal endothelial cells in cirrhosis

This study uses single-cell RNA sequencing to identify zone-specific transcriptomic changes in liver sinusoidal endothelial cells in cirrhosis, revealing Zone 3 LSECs as most susceptible to damage.

Although host-related factors are important for the formation of gut microbiota, environmental factors cannot be ignored

This study compares host-related factors and environmental factors in shaping gut microbiota using fecal samples from naval trainees and healthy individuals, finding host factors more influential.

The conserved metalloprotease invadolysin is present in invertebrate haemolymph and vertebrate blood

This study identifies invadolysin, a conserved metalloprotease present in invertebrate hemolymph and vertebrate blood, suggesting a role in organismal physiology.

No cell is an island: circulating T cell:monocyte complexes are markers of immune perturbations

The paper identifies T cell:monocyte complexes in human blood as biological immune interactions, not technical artifacts, and shows their frequency changes with immune perturbations.

High-throughput retrieval of physical DNA for NGS-identifiable clones in phage display library

The paper introduces a high-throughput platform, TrueRepertoire, for accurate clone identification and retrieval in phage display libraries, validated on a human hepatocyte growth factor-targeting scFv library.