Cancer BiologybioRxivPreprint
Darapladib, an inhibitor of Lp-PLA2, sensitizes cancer cells to ferroptosis by remodeling lipid metabolism
M. Oh, S. Y. Jang, J.-Y. Lee…·E.-W. Lee
This study shows that darapladib, an Lp-PLA2 inhibitor, enhances ferroptosis in cancer cells by altering lipid metabolism and synergizes with GPX4 inhibitors to suppress tumor growth.
DOI 10.1101/2023.04.08.536136