Pharmacology & ToxicologybioRxiv
Development of a small molecule that corrects misfolding and increases secretion of Z α1-antitrypsin
D. Lomas, J. A. Irving, C. Arico-Muendel…·A. C. Pearce
This study identifies a small molecule that stabilizes Z α1-antitrypsin, reduces polymerization, and increases its secretion in cells and mice.
DOI 10.15252/emmm.202013167