Fibronectin-integrin α5 signaling promotes thoracic aortic aneurysm in a mouse model of Marfan syndrome
M. Chen, C. Cavinato, J. Hansen, K. Tanaka, P. Ren, A. Hassab, D. S. Li, E. Joshua, G. Tellides, R. Iyengar, J. D. Humphrey, M. A. Schwartz
This study shows that fibronectin-integrin α5 signaling drives thoracic aortic aneurysms in Marfan syndrome mice, with a 5/2 chimera mutation reducing aneurysm severity.
bioRxiv · Aug 16, 2022 · PreprintPathology