P. Ren

Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis

This study uses spatiotemporal transcriptomics to analyze immune dynamics in E. multilocularis infected mouse liver, identifying key immune cell roles and shifts in immune strategy during infection.

Fluorogenic Aptamer Optimizations on a Massively Parallel Sequencing Platform

This paper optimizes a DNA-based fluorogenic aptamer (D-FAP) using a screening-and-simulation pipeline on a repurposed sequencing platform, achieving improved fluorescence properties.

Persistent lung inflammation and alveolar-bronchiolization due to Notch signaling dysregulation in SARS-CoV-2 infected hamster

This study shows SARS-CoV-2 infection in hamsters causes persistent lung inflammation and alveolar-bronchiolization linked to Notch signaling dysregulation and potential cancer risk.

Heterogeneous Cardiac- and Neural Crest-Derived Aortic Smooth Muscle Cells have Similar Transcriptional Changes after TGFβ Signaling Disruption

The paper analyzes single-cell transcriptomes of aortic smooth muscle cells in mice to show distinct origins and similar transcriptional changes after TGFβ signaling disruption.

Short-Term Disruption of TGFβ Signaling in Adult Mice Renders the Aorta Vulnerable to Hypertension-Induced Dissection

This study shows that disrupting TGFβ signaling in adult mice makes the aorta susceptible to hypertension-induced dissection, even from short-term blood pressure increases.

Habitat fragmentation mediates the mechanisms underlying long-term climate-driven thermophilization in birds

The paper examines how habitat fragmentation influences climate-driven changes in bird communities over time, finding that fragmentation affects colonization and extinction rates of warm- and cold-adapted species.

Water-Glycan Interactions Drive the SARS-CoV-2 Spike Dynamics: Insights into Glycan-Gate Control and Camouflage Mechanism

The paper uses molecular dynamics simulations to analyze water-glycan interactions in SARS-CoV-2 spike protein states, revealing structural and dynamic differences that impact immune evasion.

Less neutralization evasion of SARS-CoV-2 BA.2.86 than XBB sublineages and CH.1.1

This study compares the neutralization evasion of SARS-CoV-2 variants BA.2.86, XBB sublineages, and CH.1.1, finding BA.2.86 less evasive than XBB sublineages but CH.1.1 most evasive.

Histidine 73 methylation coordinates ????-actin plasticity in response to key environmental factors

This study uses molecular dynamics simulations to show that H73 methylation in β-actin affects nucleotide binding, allosteric pathways, and phosphate release, regulating actin plasticity in response to environmental factors.

Low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1, and XBB.1 by 4 doses of parental mRNA vaccine or a BA.5-bivalent booster

This study evaluates the neutralization effectiveness of parental mRNA vaccines and BA.5-bivalent boosters against new SARS-CoV-2 variants, showing limited neutralization against BA.2.75.2, BQ.1.1, and XBB.1.

Fibronectin-integrin α5 signaling promotes thoracic aortic aneurysm in a mouse model of Marfan syndrome

This study shows that fibronectin-integrin α5 signaling drives thoracic aortic aneurysms in Marfan syndrome mice, with a 5/2 chimera mutation reducing aneurysm severity.

Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages

This paper designs and characterizes bispecific antibodies effective against multiple SARS-CoV-2 Omicron sublineages and determines their cryo-EM structures.

Neutralization of SARS-CoV-2 Omicron sublineages by 4 doses of mRNA vaccine

This study evaluates the neutralization of SARS-CoV-2 Omicron sublineages by different vaccination regimens and finds that 4-dose mRNA vaccines provide lower neutralization compared to 2-dose plus BA.1 infection.

Neutralization of Omicron sublineages and Deltacron SARS-CoV-2 by 3 doses of BNT162b2 vaccine or BA.1 infection

This study evaluates the neutralization of Omicron sublineages and Deltacron by BNT162b2 vaccine or BA.1 infection, finding BA.4/5 shows highest evasion.

SARS-CoV-2 Delta breakthrough infections in vaccinated patients

This study assesses neutralizing antibody titers in vaccinated individuals who experienced SARS-CoV-2 Delta breakthrough infections, finding that all had titers below 70.

Cross neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2

The paper assesses cross-neutralization of Omicron BA.1 sera against BA.2, BA.3, and a pre-Omicron strain, finding reduced neutralizing titers against heterologous variants.

Heterotypic vaccination responses against SARS-CoV-2 Omicron BA.2

This study evaluates the effectiveness of WT and variant-specific mRNA vaccines against SARS-CoV-2 Omicron BA.2 subvariant using vaccinated serum from animals.

Potent and specific human monoclonal antibodies against SARS-CoV-2 Omicron variant by rapid mRNA immunization of humanized mice

This study develops RAMIHM, a method to generate potent human monoclonal antibodies against SARS-CoV-2 Omicron using mRNA immunization of humanized mice, identifying three highly effective antibodies.

Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2

This study evaluates an Omicron-specific mRNA vaccine, showing it elicits strong antibody responses and outperforms WT boosters against Omicron and Delta variants.

A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions

This paper describes a live-attenuated SARS-CoV-2 vaccine candidate with deleted ORFs that shows reduced replication and attenuation in animal models, and reports its protective efficacy against wild-type virus challenge.

Single-nucleus RNA Sequencing and Spatial Transcriptomics Reveal the Immunological Microenvironment of Cervical Squamous Cell Carcinoma

This study uses snRNA-seq and Stereo-seq to analyze the immunological microenvironment of cervical squamous cell carcinoma, identifying immune cell clusters and their associations with tumor progression and patient survival.

Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617

The paper develops and characterizes monospecific and bispecific monoclonal antibodies that neutralize SARS-CoV-2 and its variants, including B.1.617.2 Delta.

Neutralization against Omicron SARS-CoV-2 from previous non-Omicron infection

This study assesses cross-neutralization against Omicron SARS-CoV-2 from prior non-Omicron infections and finds significantly lower neutralization titers compared to the original strain.

Lonafarnib improves cardiovascular function and survival in a mouse model of Hutchinson-Gilford Progeria Syndrome

Lonafarnib improves cardiovascular function and survival in a progeria mouse model by reducing pulse wave velocity and enhancing left ventricular diastolic function.

Distinct neutralizing kinetics and magnitudes elicited by different SARS-CoV-2 variant spikes

This study shows that immunization with different SARS-CoV-2 variant spikes leads to varying neutralizing kinetics and magnitudes against other variants, with significant differences in titers between homologous and heterologous variants.

Downregulation of NCL attenuates tumor formation and growth in cervical cancer by targeting the PI3K/AKT pathway

This study shows that reducing NCL in cervical cancer cells inhibits tumor growth by suppressing the PI3K/AKT pathway and promoting apoptosis.

A trans-complementation system for SARS-CoV-2

This paper develops a trans-complementation system to produce single-round infectious SARS-CoV-2 at BSL-2 labs, enabling safe high-throughput testing without full viral replication.

Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction

The paper identifies a hydrogen-bonded junction in DNA polymerase clamp loaders that is critical for allosteric communication, preserved across diverse AAA+ ATPases.

Design of intrinsically disordered proteins that undergo phase transitions with lower critical solution temperatures

This paper designs intrinsically disordered proteins with LCST phase behavior using Monte Carlo simulations and genetic algorithms.

A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19

This paper develops a high-throughput assay using a nanoluciferase-modified SARS-CoV-2 virus to rapidly test neutralizing antibodies and antiviral drugs.