Author

E. L. Durigon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Immunology· 3 Biochemistry· 1 Cell Biology· 1 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 8 Assay:proteomics· 5 Research Focus:cell type annotation· 3 Organism:human· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

R. R. G. Machado· 3 shared A. P. Barbosa· 2 shared B. H. V. Fernandes· 2 shared B. Lee· 2 shared C. G. Bomfim· 2 shared C. R. F. Marinho· 2 shared C. Wrenger· 2 shared D. B. L. Oliveira· 2 shared

Activity by Year

2019-2021 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersImmunology

R. R. G. Machado

Mutual co-authors in cluster

Author profile →

12 papers

Recent·Most cited

Protein arginylation is regulated during SARS-CoV-2 infection

J. Macedo-da-Silva, L. Rosa-Fernandes, V. d. M. Gomes, V. F. Santiago, C. M. S. Molnar, B. R. Barboza, E. E. de Sousa, E. L. Durigon, C. R. F. Marinho, C. Wrenger, S. K. N. Marie, G. Palmisano

This study investigates how protein arginylation changes during SARS-CoV-2 infection and shows that ATE1 expression and arginylated protein levels are regulated in infected cells.

bioRxiv · Nov 2, 2021Cell Biology

Taxonomic classification methods reveal a new subgenus in the paramyxovirus subfamily Orthoparamyxovirinae

H. L. Wells, E. Loh, A. Nava, M. H. Lee, J. Lee, J. R. A. Sukor, I. Navarrete-Macias, E. Liang, C. Firth, J. Epstein, M. Rostal, C. Zambrana-Torrelio, K. A. Murray, P. Daszak, T. Goldstein, , S. J. Anthony

The paper uses taxonomic classification methods to identify a new subgenus in the Orthoparamyxovirinae subfamily based on viral genome sequences from bats.

bioRxiv · Oct 12, 2021Microbiology

Assessing the zoonotic potential of a novel bat morbillivirus

S. Ikegame, J. C. Carmichael, H. Wells, R. L. Furler O'Brien, J. A. Acklin, H.-P. Chiu, K. Y. Oguntuyo, R. M. Cox, A. R. Patel, S. Kowdle, C. S. Stevens, M. Eckley, S. Zhan, J. K. Lim, E. C. Veit, , B. Lee

This study identifies a novel bat morbillivirus, MBaMV, and assesses its zoonotic potential by showing it can infect human cells but is restricted by human immune responses.

bioRxiv · Sep 17, 2021 · PreprintMicrobiology

Neutralizing antibody-independent immunity to SARS-CoV-2 in hamsters and hACE-2 transgenic mice immunized with a RBD/Nucleocapsid fusion protein

J. Castro, M. Fumagalli, N. Hojo-Souza, P. Azevedo, N. Salazar, B. Rattis, S. Ramos, L. Faustino, G. Almeida, L. Oliveira, T. Marcal, M. Augusto, R. D. M. Magalhaes, B. Cassaro, G. Burle, , R. Gazzinelli

This study shows that a RBD/Nucleocapsid fusion protein induces strong T cell responses and protects against SARS-CoV-2 without neutralizing antibodies in hamsters and hACE-2 mice.

bioRxiv · Sep 16, 2021 · PreprintImmunology

Immunization with SARS-CoV-2 nucleocapsid protein triggers a pulmonary immune response in rats

E. K. V. B. Silva, C. G. Bomfim, A. P. Barbosa, P. Noda, I. L. Noronha, B. H. V. Fernandes, R. R. G. Machado, E. L. Durigon, S. Catanozi, L. G. Rodrigues, F. Pieroni, S. Lima, Z. A. J. Queiroz, I. Charlie-Silva, L. K. R. Silveira, , C. Fanelli

This study shows that immunizing rats with SARS-CoV-2 nucleocapsid protein induces specific lung immune responses and safe antibody production without toxicity.

bioRxiv · Aug 24, 2021 · PreprintImmunology

SARS-CoV-2 activates ER stress and Unfolded protein response

L. Rosa-Fernandes, L. C. Lazari, J. Macedo-da-Silvia, V. d. M. Gomes, R. R. G. Machado, A. F. dos Santos, D. B. Araujo, J. V. P. Coutinho, G. S. Arini, C. B. Angeli, E. E. de Souza, C. Wrenger, C. R. F. Marinho, D. B. L. Oliveira, E. L. Durigon, , G. Palmisano

This study shows SARS-CoV-2 activates ER stress and UPR pathways in infected cells, which are essential for viral replication and may be targets for antiviral drugs.

bioRxiv · Jun 21, 2021 · PreprintBiochemistry

Zebrafish studies on the vaccine candidate to COVID-19, the Spike protein: Production of antibody and adverse reaction

B. H. V. Fernandes, N. M. Feitosa, A. P. Barbosa, C. G. Bomfim, A. M. Garnique, F. I. Gomes, R. T. Nakajima, M. A. Belo, S. F. Eto, D. C. Fernandes, G. Malafaia, W. G. Manrique, G. Conde, R. R. Rosales, I. Todeschini, , Veras

This study uses zebrafish to test a COVID-19 vaccine candidate, showing antibody production and adverse reactions similar to human severe cases.

bioRxiv · Oct 20, 2020 · PreprintImmunology

Discovery of clinically approved drugs capable of inhibiting SARS-CoV-2 in vitro infection using a phenotypic screening strategy and network-analysis to predict their potential to treat covid-19

D. F. Sales-Medina, L. R. P. Ferreira, L. M. D. Romera, K. R. Goncalves, R. V. C. Guido, G. Courtemanche, M. S. Buckeridge, E. L. Durigon, C. B. Moraes, L. Freitas Junior

The paper identifies four drugs that inhibit SARS-CoV-2 in vitro infection through phenotypic screening and network analysis, providing insights for clinical repurposing.

bioRxiv · Jul 9, 2020 · PreprintMicrobiology

Ag nanoparticles-based antimicrobial polycotton fabrics to prevent the transmission and spread of SARS-CoV-2

G. C. Tremiliosi, L. G. P. Simoes, D. T. Minozzi, R. I. Santos, D. B. Vilela, E. L. Durigon, R. R. G. Machado, D. S. Medina, L. K. Ribeiro, I. L. V. Rosa, M. Assis, J. M. A. Bort, E. Longo, L. H. Freitas-Junior

This paper develops Ag nanoparticles-functionalized polycotton fabrics that inhibit SARS-CoV-2 and other pathogens with high efficacy and safety.

bioRxiv · Jun 26, 2020 · PreprintMicrobiology

Ultrastructural analysis of SARS-CoV-2 interactions with the host cell via high resolution scanning electron microscopy

L. A. Caldas, F. A. Carneiro, L. M. Higa, F. L. Monteiro, G. P. da Silva, L. J. d. Costa, E. L. Durigon, A. Tanuri, W. de Souza

This paper uses high resolution scanning electron microscopy to examine SARS-CoV-2 interactions with Vero cells at 2 and 48 hours post-infection, revealing new structural insights into viral processing and transmission.

bioRxiv · Jun 10, 2020Microbiology

Potential Outbreak in Brazil by Equine Herpesvirus Type 2 (EHV-2): Detection, Clinical and Genetic Analysis of Equine Gammaherpesvirus 2.

A. C. A. Campos, S. Cicolo, C. Monteiro de Oliveira, T. Poltronieri, L. G. Bentim Goes, V. Barbosa da Silveira, C. M. Barbosa, R. Y. Arantes Baccarin, D. B. L. Oliveira, C. B. Belli, E. L. Durigon

This paper reports the first confirmed outbreak of EHV-2 in Brazilian horses, linking the virus to respiratory disease and abortions through clinical, histopathological, and genetic analysis.

bioRxiv · Oct 17, 2019 · PreprintMicrobiology

Detection of Reticuloendotheliosis Virus in Brazil

G. S. Caleiro, C. F. Nunes, P. R. Urbano, K. Kirchgatter, J. de Araujo, E. L. Durigon, L. M. Thomazelli, B. M. Stewart, D. C. Edwards, C. M. Romano

The paper detects Reticuloendotheliosis Virus (REV) in Brazil for the first time, identifying it in Muscovy ducks, wild turkeys, and chickens with a 16.8% prevalence rate.

bioRxiv · Jul 11, 2019 · PreprintEcology