J. Castro

The RNA from Pseudomonas aeruginosa impairs neutrophil responses favoring bacterial survival

This study shows that RNA from Pseudomonas aeruginosa impairs neutrophil responses, reducing their ability to kill bacteria and promoting bacterial survival.

Modular gene interactions drive modular pan-genome evolution in bacteria.

The paper develops an evolutionary model showing that gene interactions drive modular pan-genome evolution in bacteria, with co-segregation networks reflecting gene regulatory and metabolic interactions.

The voltage-gated sodium channel NaV1.7 underlies endometriosis-associated chronic pelvic pain

This study shows that inhibiting NaV1.7 reduces endometriosis-associated chronic pelvic pain without affecting normal sensation.

The evolution of two transmissible leukaemias colonizing the coasts of Europe

This study investigates the origin and evolution of two transmissible leukaemias in common cockles, identifying clonal origins, mutational signatures, and genomic instability.

Gut Enterochromaffin Cells are Critical Drivers of Visceral Pain and Anxiety

This study shows that enterochromaffin cells drive visceral pain and anxiety through serotonin signaling, with sex differences in baseline sensitivity.

Neutralizing antibody-independent immunity to SARS-CoV-2 in hamsters and hACE-2 transgenic mice immunized with a RBD/Nucleocapsid fusion protein

This study shows that a RBD/Nucleocapsid fusion protein induces strong T cell responses and protects against SARS-CoV-2 without neutralizing antibodies in hamsters and hACE-2 mice.

Autoregulatory control of microtubule binding in the oncogene, doublecortin-like kinase 1

This study identifies autophosphorylation as a mechanism regulating DCLK1 kinase activity and microtubule binding affinity, offering insights into its role in cancer.