Interplay between intrinsic reprogramming potential and microenvironment controls neuroblastoma cell plasticity and identity
C. Thirant, A. Peltier, S. Durand, A. Kramdi, C. Louis-Brennetot, C. Pierre-Eugene, A. Costa, A. Grelier, S. Zaidi, N. Gruel, I. Jimenez, E. Lapouble, G. Pierron, H. Brisse, A. Gauthier, , I. Janoueix-Lerosey
This study shows that neuroblastoma cells can switch between noradrenergic and mesenchymal identities through epigenetic reprogramming, influenced by both intrinsic factors and the microenvironment.
bioRxiv · Jan 7, 2021 · PreprintCancer Biology