S. Zaidi

The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1

This study identifies ASCL1 as a critical driver of neuroendocrine lineage transition in prostate cancer using an in vivo model and spatial transcriptomics.

Single Cell Analysis of Treatment-Resistant Prostate Cancer: Implications of Cell State Changes for Cell Surface Antigen Targeted Therapies

The paper uses single-cell analysis to study how cell surface antigen expression changes in treatment-resistant prostate cancer, revealing transcriptional heterogeneity and shared gene regulatory networks between NEPC and SCLC.

Conditional deletion of CEACAM1 causes hepatic stellate cell activation

This study shows that CEACAM1 loss in hepatic stellate cells (HSCs) activates them, leading to myofibroblastic transformation and fibrosis without insulin resistance or steatosis.

Reversal of lineage plasticity in RB1/TP53-deleted prostate cancer through FGFR and Janus kinase inhibition

This study identifies a pharmacological strategy to reverse lineage plasticity in prostate cancer by inhibiting FGFR and Janus kinase pathways.

Multilineage plasticity in prostate cancer through expansion of stem-like luminal epithelial cells with elevated inflammatory signaling

The paper identifies stem-like luminal cells with elevated JAK/STAT signaling as a source of multilineage plasticity in prostate cancer, offering a therapeutic target.

Integrative genomics uncover mechanisms of renal medullary carcinoma transformation, microenvironment landscape and therapeutic vulnerabilities.

This study uses single-cell and multi-region sequencing to define RMC transformation, identify cell states, and uncover therapeutic vulnerabilities through transcriptional changes and microenvironment interactions.

Interplay between intrinsic reprogramming potential and microenvironment controls neuroblastoma cell plasticity and identity

This study shows that neuroblastoma cells can switch between noradrenergic and mesenchymal identities through epigenetic reprogramming, influenced by both intrinsic factors and the microenvironment.

RUNX1 mitotically bookmarks target genes that are important for the mammary epithelial-to-mesenchymal transition

This study identifies RUNX1 as a mitotic bookmarking factor that maintains epithelial gene expression and prevents EMT in mammary cells.

Transcriptional programs define intratumoral heterogeneity of Ewing sarcoma at single cell resolution

This study identifies transcriptional programs driving intratumoral heterogeneity in Ewing sarcoma using single-cell RNA-sequencing and chromatin analysis.

Dynamic changes in innate immune and T cell function and composition at the nasal mucosa across the human lifespan

This study examines age-related changes in nasal mucosal immune composition and function, finding reduced granulocytes and T cells in young children and older adults, and links pneumococcal colonization to inflammation.

Inflammation induced by influenza virus impairs innate control of human pneumococcal carriage

This study shows that influenza virus infection impairs innate immune responses to pneumococcal carriage in the nose, increasing bacterial density through cytokine-driven mechanisms.

Effect of Live Attenuated Influenza Vaccine on Pneumococcal Carriage

This study tests if LAIV affects pneumococcal carriage in humans, finding transient increases in bacterial density but no overall change in acquisition rates.