A. Costa

Abiotic stress-induced chloroplast and cytosolic Ca2+ dynamics in the green alga Chlamydomonas reinhardtii

This study investigates compartment-specific Ca2+ dynamics in Chlamydomonas reinhardtii under abiotic stress, revealing distinct responses in chloroplasts and cytosol.

MCM Double Hexamer Loading Visualised with Human Proteins

The paper characterizes human MCM double hexamer (hDH) loading using biochemical reconstitution and cryo-EM, revealing differences from yeast in assembly mechanisms and identifying a novel intermediate.

Cell Cycle Regulation has Shaped Budding Yeast Replication Origin Structure and Function

The paper shows that CDK regulation influences MCM helicase loading at yeast origins, revealing how cell cycle control has shaped origin structure and function.

A pectin-binding peptide with a structural and signaling role in the assembly of the plant cell wall

The paper identifies RALF22 as a peptide that functions both structurally and signaling in plant cell wall assembly, forming complexes with LRX1 and LLG1-FER to regulate cell expansion.

Paenibacillus sp. strain UY79, isolated from a root nodule of Arachis villosa, displays a broad spectrum of antifungal activity

This study identifies a new Paenibacillus species with broad antifungal activity and biocontrol potential, showing it can inhibit multiple plant pathogens and modulate soil bacterial communities.

Interplay between intrinsic reprogramming potential and microenvironment controls neuroblastoma cell plasticity and identity

This study shows that neuroblastoma cells can switch between noradrenergic and mesenchymal identities through epigenetic reprogramming, influenced by both intrinsic factors and the microenvironment.

Ribosomes act as cryosensors in plants

The paper shows that reduced translation rates in plants trigger calcium increases, activating CAMTA transcription factors that drive cold-induced gene expression.

The eukaryotic replisome requires an additional helicase to disarm dormant replication origins

The paper shows that Pif1 helicase, along with the replisome, removes unfired MCM DHs from replicating DNA, enabling efficient replication and termination.

Pharmacological and genetic manipulations of Ca2+ signaling have contrasting effects on auxin-regulated trafficking

The paper investigates how pharmacological and genetic manipulations of Ca2+ signaling affect auxin-regulated PIN trafficking, finding contrasting results between exogenous Ca2+ manipulations and genetic mutants.

Testing the predictability of morphological evolution in contrasting thermal environments

This study shows that morphological responses to temperature changes can be predictable in populations with limited gene flow, but less so when gene flow is present.

DRT111/SFPS splicing factor controls ABA sensitivity in Arabidopsis seed development and germination

This study shows that DRT111/SFPS splicing factor regulates ABA sensitivity in Arabidopsis seed development and germination by controlling splicing of ABI3 and interacting with SF1 and SUA.

Microtubule Nucleation by Single Human γTuRC in a Partly Open Asymmetric Conformation

This study characterizes the nucleation properties of human γTuRC using TIRF microscopy and cryo-EM, revealing an asymmetric conformation that explains its kinetic inhibition of microtubule nucleation.

Ecological networks: Pursuing the shortest path, however narrow and crooked

The paper analyzes ecological network studies using shortest paths, identifying methodological issues in edge weight handling and proposing a checklist for better practices.

GUN1 influences the accumulation of NEP-dependent transcripts and chloroplast protein import in Arabidopsis cotyledons upon perturbation of chloroplast protein homeostasis

This study shows GUN1 affects NEP-dependent transcript accumulation and chloroplast protein import in Arabidopsis cotyledons under conditions of chloroplast protein homeostasis disruption.

Retroviral integration into nucleosomes throughDNA looping and sliding along the histone octamer

This study reveals that retroviral integrase uses a looping-and-sliding mechanism to reposition nucleosomal DNA for integration, similar to chromatin remodelers.

The right microbial stimulus can direct innate immune effector cells to specific organ sites to clear pathology

This paper demonstrates that microbial-based stimuli can direct innate immune effector cells to specific organs to clear pathology, independent of the disease type.

On the Calculation of Betweenness Centrality in Marine Connectivity Studies Using Transfer Probabilities

The paper addresses inconsistencies in calculating betweenness centrality using transfer probabilities in marine connectivity studies and proposes a new node-to-node distance metric.

ATP sensing in living plant cells reveals tissue gradients and stress dynamics of energy physiology

The paper develops a fluorescent biosensor to measure MgATP2- dynamics in living plant cells, revealing tissue-specific gradients and stress responses in ATP homeostasis.