The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming
A. R. Cole, R. Buj, A. Uboveja, E. Levasseur, H. Wang, K. M. Kedziora, A. Chatoff, A. Andress Huacachino, M. M. Marcinkiewicz, A. Amalric, B. Yang, N. K. Tangudu, J. Danielson, A. Taher Elhaw, S. White, , K. M. Aird
This study shows that chemotherapy-induced senescence-associated secretome promotes metastasis in ovarian cancer by reprogramming metabolism and increasing cell detachment.
bioRxiv · Dec 2, 2023Cancer Biology