Author

A. Chatoff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

N. W. Snyder· 4 shared A. Amalric· 2 shared A. R. Cole· 2 shared A. Uboveja· 2 shared B. G. Bitler· 2 shared D. Kantner· 2 shared E. Megill· 2 shared H. Wang· 2 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

N. W. Snyder

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

αKG-mediated carnitine synthesis promotes homologous recombination via histone acetylation

A. Uboveja, Z. Huang, R. Buj, A. Amalric, H. Wang, N. K. Tangudu, A. R. Cole, E. Megill, D. Kantner, A. Chatoff, H. Ahmad, M. M. Marcinkiewicz, J. A. Disharoon, S. Graff, E. S. Dahl, , K. M. Aird

This study shows that αKG-mediated carnitine synthesis supports HR proficiency by promoting histone acetylation, which enhances DNA repair.

bioRxiv · Feb 6, 2024Cancer Biology

The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming

A. R. Cole, R. Buj, A. Uboveja, E. Levasseur, H. Wang, K. M. Kedziora, A. Chatoff, A. Andress Huacachino, M. M. Marcinkiewicz, A. Amalric, B. Yang, N. K. Tangudu, J. Danielson, A. Taher Elhaw, S. White, , K. M. Aird

This study shows that chemotherapy-induced senescence-associated secretome promotes metastasis in ovarian cancer by reprogramming metabolism and increasing cell detachment.

bioRxiv · Dec 2, 2023Cancer Biology

Dynamic protein deacetylation is a limited carbon source for acetyl-CoA-dependent metabolism

I. Soaita, E. Megill, D. Kantner, A. Chatoff, Z. Arany, N. W. Snyder, K. E. Wellen, S. W. Trefely

This study shows that dynamic protein deacetylation in Acly-/- MEFs contributes carbons to acetyl-CoA but only transiently supplies about 9% of cellular acetyl-CoA.

bioRxiv · Dec 28, 2022Biochemistry

Genetic depletion of de novo coenzyme A biosynthesis exacerbates puromycin toxicity

S. Khadka, A. Chatoff, N. W. Snyder, R. A. DePinho, F. L. Muller

The paper shows that reducing coenzyme A biosynthesis increases cancer cells' sensitivity to puromycin, a selection antibiotic used in research.

bioRxiv · Sep 6, 2022 · PreprintCancer Biology