Author

A. R. Cole

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Amalric· 3 shared A. Uboveja· 3 shared K. M. Aird· 3 shared N. K. Tangudu· 3 shared N. W. Snyder· 3 shared R. Buj· 3 shared B. Yang· 2 shared H. Wang· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCancer Biology

A. Amalric

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cancer BiologybioRxivDec 2, 2023

The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming

A. R. Cole, R. Buj, A. Uboveja…·K. M. Aird

This study shows that chemotherapy-induced senescence-associated secretome promotes metastasis in ovarian cancer by reprogramming metabolism and increasing cell detachment.

DOI 10.1038/s43587-026-01172-5

humanbulk RNA-seq

𝕏 PostBluesky

Cell BiologybioRxivOct 27, 2023

ATR promotes mTORC1 activity via de novo cholesterol synthesis

N. K. Tangudu, A. N. Grumet, R. Fang…·K. M. Aird

This study shows ATR enhances mTORC1 activity through cholesterol synthesis via LSS, independent of CHK1 and TSC, and this effect is amplified in p16-deficient cells.

DOI 10.1038/s44319-025-00451-3

humanexperimental assay

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Cancer BiologybioRxivJul 15, 2023

De novo purine metabolism is a metabolic vulnerability of cancers with low p16 expression

N. K. Tangudu, R. Buj, H. Wang…·K. M. Aird

This study identifies de novo purine metabolism as a vulnerability in cancers with low p16 expression, showing sensitivity to anti-folate drugs like methotrexate.

DOI 10.1158/2767-9764.crc-23-0450

humanmouse

𝕏 PostBluesky

BiochemistrybioRxivNov 30, 2020

Characterization of SARS-CoV-2 N protein reveals multiple functional consequences of the C-terminal domain

C. Wu, A. J. Qavi, A. Hachim…·D. W. Leung

This study characterizes the SARS-CoV-2 N protein, identifying domain-specific functions and highlighting the C-terminal domain's immunogenicity for diagnostic applications.

DOI 10.1016/j.isci.2021.102681

humanproteomics

𝕏 PostBluesky