A yeast-based system to study SARS-CoV-2 Mpro structure and to identify nirmatrelvir resistant mutations
J. Ou, E. Lewandowski, Y. Hu, A. Lipinski, R. Morgan, L. Jacobs, X. Zhang, M. Bikowitz, P. Langlais, H. Tan, J. Wang, Y. Chen, J. S. Choy
This study uses a yeast-based system to identify nirmatrelvir-resistant mutations in SARS-CoV-2 Mpro and confirms findings with structural analysis.
bioRxiv · Aug 6, 2022 · PreprintMicrobiology