H. Tan

HKDC1 Promotes Liver Cancer Stemness Under Hypoxia via Stabilizing β-Catenin

This study identifies HKDC1 as a prometastatic enzyme in liver cancer that stabilizes β-catenin under hypoxia, enhancing cancer stemness.

Design of SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model

The paper designs SARS-CoV-2 PLpro inhibitors that show antiviral efficacy in a mouse model against SARS-CoV-2 and its variants.

Neurophysiological Features of STN LFP underlying Sleep Fragmentation in Parkinson's Disease

This study identifies STN LFP features, including beta and gamma oscillations and the low-high power ratio, that correlate with sleep fragmentation in Parkinson's disease patients.

Theranostic Bottle-Brush Polymers Tailored for Universal Solid-Tumour Targeting

This study develops bottle-brush polymers optimized for tumour targeting, showing improved delivery efficacy and reduced toxicity in various tumour models.

SoMAS: Finding somatic mutations associated with alternative splicing in human cancers

SoMAS identifies somatic mutations linked to alternative splicing in 33 cancer types, revealing 908 genes associated with altered isoform expression across multiple cancers.

Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing is associated with therapeutic response to splicing inhibitor

This study shows JMJD6 links pre-mRNA splicing and metabolism in MYC-driven cancers, and its inhibition enhances therapeutic response to splicing inhibitors.

Ribonucleotide Reductase Subunit Switching in Hepatoblastoma Drug Response and Relapse

This study identifies RRM2 and RRM2B as key players in hepatoblastoma progression and drug response, showing their dynamic switching and impact on relapse.

The maternal microbiome regulates infant respiratory disease susceptibility via intestinal Flt3L expression and plasmacytoid dendritic cell hematopoiesis

The paper shows that a maternal low-fibre diet disrupts infant immune development, increasing susceptibility to respiratory infections and asthma, and that propionate-producing bacteria can reverse this effect.

A plant virus causes symptoms through the deployment of a host-mimicking protein domain to attract the insect vector

This study identifies how the tomato yellow leaf curl virus uses a host-mimicking protein domain to disrupt plant processes and attract insect vectors, facilitating viral spread.

Dispersal provides trophic-level dependent insurance against a heatwave in freshwater ecosystems

The paper tests how dispersal from natural lakes affects community resilience to a heatwave in alpine lake plankton, finding that microorganism dispersal enhances recovery while zooplankton dispersal does not.

A yeast-based system to study SARS-CoV-2 Mpro structure and to identify nirmatrelvir resistant mutations

This study uses a yeast-based system to identify nirmatrelvir-resistant mutations in SARS-CoV-2 Mpro and confirms findings with structural analysis.

Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir

The study identifies SARS-CoV-2 Mpro mutations associated with nirmatrelvir resistance from clinical isolates.

Histone H3K4 methyltransferase DcATX1 promotes ethylene induced petal senescence in carnation

This study identifies DcATX1 as a histone methyltransferase that accelerates ethylene-induced petal senescence in carnation by regulating H3K4me3 levels and gene expression.

Validation and invalidation of SARS-CoV-2 main protease inhibitors using the Flip-GFP and Protease-Glo luciferase assays

This study validates and invalidates SARS-CoV-2 main protease inhibitors using cell-based and cell-free assays, showing most repurposed drugs are not specific to Mpro.

Combinatorial interactions between viral proteins expand the functional landscape of the viral proteome

This study shows that viral proteins interact combinatorially, leading to new biological functions beyond their individual roles during infection.

Geminiviral genomes encode additional proteins with specific subcellular localizations and virulence function

This study identifies additional ORFs in geminiviral genomes that encode small proteins with specific subcellular localizations and virulence functions.

Unique intramolecular oxidative rearrangement N-nitrosation mechanism of non-heam iron-containing enzyme SznF

This paper investigates the catalytic mechanism of SznF, revealing an unusual N-nitrosation pathway involving electron shuttling without high-valent iron species.

Interactive regulation between aliphatic hydroxylation and aromatic hydroxylation of thaxtomin D in TxtC, a theoretical investigation

This paper investigates how TxtC catalyzes sequential hydroxylation of thaxtomin D, revealing that aliphatic hydroxylation is preferred due to lower energy barriers and conformational changes induced by intermediate hydroxyl groups.

Plant DNA polymerases alpha and delta mediate replication of geminiviruses

This study identifies DNA polymerases alpha and delta as key mediators of geminivirus replication in plants, with C3 protein selectively recruiting polymerase delta for efficient viral genome synthesis.

On the origin and evolution of RNA editing in metazoans

The paper investigates the origin and evolution of A-to-I RNA editing in metazoans, finding it emerged in the common ancestor and is nonadaptive in most regions except for specific taxa.

A novel pathway linking plasma membrane and chloroplasts is co-opted by pathogens to suppress salicylic acid-dependent defences

This study identifies a pathway connecting plasma membrane and chloroplasts that pathogens exploit to suppress salicylic acid-dependent defenses.

Structural basis of recruitment of RBM39 to DCAF15 by a sulfonamide molecular glue E7820

The paper investigates how E7820 recruits RBM39 to the DCAF15 E3 ligase complex through structural and kinetic analysis, revealing its mechanism as a molecular glue.

New mechanism-based inhibitors of aspartate transcarbamoylase for anticancer drug development

This study identifies new ATCase inhibitors by targeting a previously unknown regulatory region and active site, showing strong anticancer effects in cell lines and xenograft models.

Structure-Unbinding Kinetics Relationship of p38 MAPK Inhibitors

The paper investigates unbinding kinetics of two p38 MAPK inhibitors using simulations, revealing that hydrophobic and hydrogen-bonding interactions in the R1 group influence unbinding rates.

Establishment of baseline sensitivity of Rhizoctonia solani to thifluzamide in corn and its field application

This paper evaluates the sensitivity of Rhizoctonia solani to thifluzamide in corn and assesses the effectiveness of seed coating with thifluzamide suspension agent in improving physiological indicators and controlling banded leaf sheath blight.