Author

E. M. Schleicher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

G.-L. Moldovan· 3 shared A. Dhoonmoon· 2 shared C. M. Nicolae· 2 shared K. E. Clements· 2 shared A. M. Galvan· 1 shared C. L. Stump· 1 shared C. Nicolae· 1 shared L. M. Jackson· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 18 mutual co-author links

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3 shared papersCancer Biology

G.-L. Moldovan

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3 papers

Recent·Most cited

Cancer BiologybioRxivApr 8, 2020

Dual genome-wide CRISPR knockout and CRISPR activation screens identify common mechanisms that regulate the resistance to multiple ATR inhibitors

E. M. Schleicher, A. Dhoonmoon, K. E. Clements…·G.-L. Moldovan

The paper uses dual CRISPR screens to identify genes affecting resistance to ATR inhibitors in cancer cells.

DOI 10.1371/journal.pgen.1009176

humangenetic perturbation / CRISPR

𝕏 PostBluesky

Cancer BiologybioRxivApr 8, 2020

Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP- ribosyltransferase PARP14 in replication fork stability controlled by ATR

A. Dhoonmoon, E. M. Schleicher, C. M. Nicolae…·G.-L. Moldovan

The paper identifies PARP14's role in replication fork stability through a CRISPR screen, showing its dependence on the ATR-CHK1 pathway.

DOI 10.1093/nar/gkaa508

humangenetic perturbation / CRISPR

𝕏 PostBluesky

Cancer BiologybioRxivJun 2, 2018

PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stress

E. M. Schleicher, A. M. Galvan, G.-L. Moldovan, C. Nicolae

This study shows PARP10 promotes cell proliferation and tumorigenesis by reducing replication stress through fork restart and DNA repair.

DOI 10.1093/nar/gky658

humangenetic perturbation / CRISPR

𝕏 PostBluesky