Structural and functional characterization of ubiquitin variant inhibitors for the JAMM-family deubiquitinases STAMBP and STAMBPL1
Y. Guo, Q. Liu, E. Mallette, C. Caba, F. Hou, J. Fux, G. LaPlante, A. Dong, Q. Zhang, H. Zheng, Y. Tong, W. Zhang
This paper develops Ub variant inhibitors for JAMM-family DUBs STAMBP and STAMBPL1, showing high affinity and selectivity, with structural insights and improved potency over existing inhibitors.
bioRxiv · Jul 16, 2021Biochemistry