F. Hou

Observation of Higher-Order Assemblies Controlled by Protein One-dimensional Movement

The paper investigates how MDA5 CARDs assemble and interact with LGP2 through one-dimensional movement along dsRNA to regulate immune response.

Novel mRNA vaccines encoding Monkeypox virus M1R and A35R protect mice from a lethal virus challenge

This paper develops mRNA vaccines against Monkeypox virus that protect mice from lethal infection, with fusion protein vaccines showing better immune responses than separate protein vaccines.

Integrative interactome and ubiquitinome analyses reveal multiple regulatory pathways targeted by ICP0 in HSV-1 infected neuronal cells

This study identifies and validates multiple novel targets of HSV-1 ICP0 in neuronal cells using proteomic approaches and functional experiments, revealing potential restrictive activities of SNX9 and OTUD4.

Structural and functional characterization of ubiquitin variant inhibitors for the JAMM-family deubiquitinases STAMBP and STAMBPL1

This paper develops Ub variant inhibitors for JAMM-family DUBs STAMBP and STAMBPL1, showing high affinity and selectivity, with structural insights and improved potency over existing inhibitors.

Are pangolins the intermediate host of the 2019 novel coronavirus (2019-nCoV) ?

This study analyzes pangolin coronaviruses to assess their role as potential intermediate hosts of SARS-CoV-2, finding genetic relatedness but not direct origin.

Ubiquitin-dependent and -independent roles of E3 ligase RIPLET in innate immunity

RIPLET functions as a molecular glue to assemble signaling scaffolds for the antiviral innate immune receptor RIG-I.

Garcinia cambogia extract removes calcium oxalate kidney stones in both genetic and non-genetic Drosophila models of nephrolithiasis

This study shows Garcinia cambogia extract removes calcium oxalate kidney stones in Drosophila models, suggesting a potential therapeutic strategy for nephrolithiasis.