Evolutionary BiologybioRxiv
Machine-learning dissection of Human Accelerated Regions in primate neurodevelopment
S. Whalen, F. Inoue, H. Ryu…·K. S. Pollard
The paper uses machine learning to analyze human-chimpanzee variants in HARs, finding 43% affect chromatin state and 14% affect neurodevelopmental enhancer activity, with species-specific activity predicted by transcription factor footprints.
DOI 10.1016/j.neuron.2022.12.026