S. Whalen

The paper identifies human-specific 3D genome re-wiring in conserved loci, linking accelerated evolution to regulatory rewiring in neural progenitor cells.

The paper uses machine learning to analyze human-chimpanzee variants in HARs, finding 43% affect chromatin state and 14% affect neurodevelopmental enhancer activity, with species-specific activity predicted by transcription factor footprints.

This paper shows that the Epstein-Barr virus episome shifts between repressive and active nuclear compartments during latency and reactivation, using interchromosomal interactions to regulate transcription.