Stress-induced Rab11a-exosomes induce AREG-mediated cetuximab resistance in colorectal cancer
J. D. Mason, E. Marks, S.-J. Fan, K. McCormick, C. Wilson, A. L. Harris, F. C. Hamdy, C. Cunningham, D. C. I. Goberdhan
This paper shows that stress-induced Rab11a-exosomes carrying AREG promote cetuximab resistance in colorectal cancer by activating EGFR signaling in KRAS-wild type cells.
bioRxiv · Dec 19, 2023 · PreprintCancer Biology